Generally, point releases for macOS are reliable enough to update, so I downloaded the latest version (released a week ago or so). Unfortunately, I've been experiencing beeps and stutters with audio through USB audio devices. On-board doesn't have issues.
It's a 13 inch MBP 2015.
I managed to reduce the problem drastically with a PRAM reset and clearing out some crap, but it's still there, once every five minutes or so.
I'm not the only one either. https://discussions.apple.com/message/31568955
So looks like I have the fun task of rolling back to 10.12.3 before my next party, unless a fix comes out before.
Anyone else had problems?