To put a finer point on the flexibility of 4 v. 2 is that you have more routing options for EFX units, signal sources (TT, CDJ, software or another computer). If the mixer is digital like the DNX1600/1700, Xone DB4 one can route audio bi-directionally, i.e. from laptop to mixer and back again allowing for some creative sound shaping. Depends on what you wish to do though i guess. I tend to think of mixers now-a-days as more of a spoke hub for audio than a way to pass signal from A to B. There are a number of videos for the 1700 and DB4 hi-lighting their ability to do unconventional routing.
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