Exactly what I was going to post. You need to go into TP2 settings and turn on the crossfader and you'll see three digital representations of the mix/cue/mic volumes on the front of the S4. If the middle "knob" appears to be all the way down (left), no movement on the S4's knob will activate it. Think of it as a master volume. Once you have the TP2 "knob" up to about halfway you can use the physical knob on the S4 to screw around with your volume.
I freaked out a bit too when this happened to me too haha.
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