this
But seriously, you have to. Unless you are doing end zone mixes all night you better be mixing harmonically or at least something close to it. I think Photojojo is right tho in that if you are mixing songs that sound like they go together, chances are they are either in the same key, or work with the cirlce of 5ths regardless if you realize it or not.
I myself start out with rapid evolution open, my wheel of 5ths, and start building my sets from there because it saves me time. I can go to the appropriate keys and see which of my songs i can mix harmonically in to. If the songs fit and are in the right key, this is obviously the best scenario. Often they don't tho in which case I switch gears and continue to mix harmonically from the new key. I'm not sure why you WOULDN'T mix harmonically. Music theory telling you which keys sound good together exists for a reason. To not use that information is kind of foolish imo.
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