I used to have USB issues with one usb port with serato sl1 box.
try this if you haven't already
Resetting the SMC for Mac Pro, Intel-based iMac, Intel-based Mac mini, or Intel-based Xserve
1. Shut down the computer.
2. Unplug the computer's power cord.
3. Press and hold the power button for 5 seconds.
4. Release the power button.
5. Attach the computers power cable.
6. Press the power button to turn on the computer.
This resets the power distribution to all ports
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