Wavs do sound different/better, at least on studio monitors. I'd assume they sound different on huge systems as well. Do they sound different enough to be worth the hassle? Not for me. I don't use Wav, and as far as I'm aware none of the DJs I've talked to in my area do either (it's the type of thing I'd expect to get brought up too). I'm sure I'll get flamed for this next sentence, but here it goes. Honestly, in my experience the sound quality difference between an S4 and a proper external mixer/decent soundcard (Mackie d.4 pro, then my DJM900) is more substantial than the difference between Wav and MP3. You might be getting better results with your S4 than I did, but I found it really killed the dynamics in my tracks in comparison.
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