Yes! I've run 2 just as you've described. I've also run... many more than two. There were no conflicts whatsoever.
I do have several recommendations, though. I almost always use instances of the VST like this:
http://forum.djtechtools.com/showthread.php?t=48092
I would grab a great USB hub that has buttons or switches to turn each port on and off. Maschines don't have power switches and I don't like the system of plugging and unplugging them all the time, so this is really nice and clean.
The new remote script for the mkii controller and Ableton is incredimazing and highly recommended. It has a number of features shared by the upcoming Push - colour coded scales, etc.
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