It would be awesome if we can change those settings on the fly.
I don't think they're going to develop that because apparently the controller needs to restart, so it cannot be "on the fly" as Noofny said. (Thanks Noofny for your findings!)

In a live enviroment its imposible but for a production enviroment maybe one can wait to the thing to restart after the new sysex is sent.

It would be awesome to isolate the sysex chunks for each config and encoder to build some "snippets" and update that config on demand, besides the reset.